The etiologrointestinal stromal tumor contagiousy of gastrointestinal stromal tumor Is gast

1. Etiology of gastrointestinal stromal tumors.

The main cause of GIST is KIT or PDGFRA gene activation mutation, which leads to abnormal continuous activation of tyrosine kinase, abnormal activation of tyrosine kinase signal to ^ downstream, leading to the continuous growth of tumor cells. KIT gene is a proto-oncogene in the human body, which is related to cell proliferation and is necessary to maintain the normal life activities of the body. The encoded CD117 protein is positive in more than 95% of GIST patients.