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Pathogenesis of ovarian germ cell tumor

August 17, 2023


The peak age of ovarian germ cell tumor was 15-19 years old. Among them, 1ax 3 is a malignant tumor. Ovarian germ cell tumors grow rapidly, about 85% of patients have abdominal and pelvic pain or pressure, physical examination can touch the mass, often have tumor rupture, bleeding and tumor pedicle torsion, symptoms similar to acute appendicitis. Due to the production of hormones such as B β _ hCG and estrogen, a small number of patients may have prepubertal precocious puberty. Due to the high incidence of ovarian germ cell tumors during the growth period. It is common in pregnant women. In a survey of more than 9000 cases of adnexal mass during pregnancy, 44% of 81 malignant tumors were germ cell tumors, of which dysgerminoma was the most common (41%).



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70% of the patients were classified as I~III stage according to FIGO stage, and the other 30% were divided into two stages. The vast majority of germ cell tumors are unilateral, with the exception of dysgerminoma (10%-15% bilateral). Twenty-six cases of dysgerminoma were investigated in the past 15 years, and 23% of them were bilateral. Bilateral tumors do not mean that they are malignant tumors. 5% to 10% of benign teratomas are bilateral tumors.

The diagnosis was made according to the patient's medical history and physical examination. As malignant asexual cell tumors often have abnormal sex chromosomes, clinical attention should be paid to the presence of menstruation and secondary sexual characteristics. Therefore, preoperative karyotype examination is very important. The following tests should also be performed for all patients: blood routine, liver function and tumor markers, and optional imaging examinations, such as pelvic ultrasonography. Most of the asexual cell tumors are solid and may have bleeding manifestations. Ultrasound examination shows solid masses. Teratoma and endodermal sinus tumor are cystic and solid masses.

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